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73 A post hoc analysis suggested that a higher proportion of insulin-resistant patients in the phase 2 trial may have contributed to the discrepant results, because Exenatide PD3 showed a non-significant trend toward benefit only in the small insulin-resistant subgroup
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The cardiovascular and metabolic benefits of tirzepatide may outweigh the NAION risk, but this requires individualized discussion with both your prescribing provider and an ophthalmologist
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